Pure Rawz RAD 140, also known as Testolone, is a non-steroidal selective androgen receptor modulator (SARM). Like other SARMs, it is being studied for its potential to bind to specific androgen receptors and as a result does not cause the full spectrum of androgenic effects as similar substances like anabolic steroids, DHT, or testosterone replacement therapy.
Testolone hasn’t been around for long. In fact, this research compound was developed in 2010 as a potential treatment for osteoporosis. At the time of writing, it is mostly being investigated as a research compound with the potential ability to enhance muscle hypertrophy and promote muscular gains.
Research has shown that the stability of RAD-140 is high in incubations with rats, monkeys, and human microsomes. The research compound has also demonstrated good bioavailability in rats and monkeys as well as an excellent affinity for the androgen receptor in skeletal tissue.
Recent studies investigated the effects of RAD-140 on levator ani muscle weight and prostate weight in castrated rats, which are sensitive markers of anabolic-androgenic action in young nonhuman primates. The final results showed that RAD-140 stimulates the levator ani muscle.
Multiple animal studies have been conducted on RAD-140. This research compound has also undergone numerous clinical trials or human studies. In this section, we’re going to highlight what research has unearthed so far about this research compound.
However, it must be understood that the Food and Drug Administration (FDA) hasn’t approved RAD-140 for human use. This compound should be used for laboratory research use only and is not intended for human consumption.
In a study involving rats, scientists investigated the potential ability of RAD-140 to offer neuroprotection in cultured rat neurons and male rat brains. In cultured hippocampal neurons, RAD-140 was observed to be as effective as testosterone in reducing cell death induced by apoptotic insults.
In experiments with gonadectomized male rats, RAD-140 exhibited neuroprotection of hippocampal neurons against cell death caused by systemic administration of the excitotoxin kainate, highlighting its preclinical efficiency in neuroprotective actions relevant to Alzheimer’s disease.
RAD-140 and Muscle Mass
One study investigated the anabolic effects of RAD-140 in young, male cynomolgus monkeys. Researchers examined gross body weight, which we know to be a sensitive marker of anabolic androgen action in young nonhuman primates.
While there was no consistent effect on absolute fat mass, the muscle mass showed a qualitative trend that increased with dosage. It appeared that the majority of muscle mass increase was due to lean mass increase. This shows the immense promise of potential muscular gains brought on by RAD-140.
In short, research suggests that RAD-140 may increase lean muscle. If the RAD 140 dosage is limited, however, these effects will be limited in subjects.
RAD-140 and Breast Cancer
RAD-140 is currently under investigation as a potential treatment for breast cancer.
In a cell study, oral administration of RAD-140 inhibited the growth of AR/ER+ breast cancer via the androgen receptor-mediated suppression of the ESR1 gene, both as a single agent and in combination with palbociclib (prescription medicine for certain types of breast cancer).
Androgen and estrogen-receptor-positive (AR/ER+) is a common form of breast cancer. It is sensitive to hormones, and therefore, medications that affect these receptors, such as SARMs like RAD 140, which are being investigated for their cancer-fighting potential.
RAD-140 FAQs
How Does RAD-140 Work?
RAD-140 works by selectively targeting androgen receptors in the muscle and bone tissue, leading to a potential increase in lean muscle mass and a decrease in body fat.
This distinguishes RAD, as well as other SARMs, from anabolic steroids, testosterone, and DHT which do not spare androgen receptors in the reproductive organs.
Is RAD-140 Legal?
RAD-140 is legal to buy and sell as a research compound.
However, since this drug is on the World Anti-Doping Agency’s (WADA’s) list, it cannot be used by athletes and professionals. It is also illegal for human consumption.
What Is The Half-Life of RAD-140?
There are conflicting reports about the half-life of RAD 140. While some reports put the half-life at 16 hours, other researchers state that the compound has a long half-life of up to 60 hours.
Does RAD-140 Cause Testosterone Suppression?
According to a study conducted in 2010, 28 days of dosing with RAD 140 suppressed testosterone levels by approximately 200 – 300 ng/dL, with similar suppression in all three groups, although testosterone levels were significantly different for only the 0.01mg/kg group (p < 0.05).
Does RAD-140 Cause Acne in Subjects?
There is no mention of RAD 140 causing acne in this drug’s various animal studies.
Is RAD-140 Orally Bioavailable?
In pre-clinical characterisation, this research compound had good bioavailability in rats and monkeys. Further research is needed to verify its bioavailability in humans.
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