SARMs MK 677, also known as Ibutamoren, Oratrope, or Nutrobal (molecular weight 528.662), is a ghrelin agonist that acts on the pituitary gland as a human growth hormone secretagogue and is sometimes classified along with selective androgen receptor modulators (SARMs).
It differs from Ghrelin itself in that it is not a peptide but rather a spiropiperidine. Since it can cross the blood-brain barrier, MK-677 functions as a neuropeptide in the central nervous system.
MK 677 vs other Growth Hormone Secretagogues
It is a very powerful hormone and it is not uncommon to find Ibutamoren and SARMs for sale in the same catalog. Data shows that MK-677 has an advantage over compounds like GHRP-6 and GHRP-2 in that it elevates IGF-1 levels for 24 hours after a single dose without inhibiting natural pulsatile growth hormone release.
Since it does not exert its effect via androgen receptor, it is believed that MK677 may improve body composition without negatively impacting endogenous androgen secretion like Testosterone and other anabolic compounds. Some data also suggests that MK677 may have synergistic effects when combined with growth hormone releasing peptides like Tesamorelin or Ipamorelin.
MK 677 Benefits from Clinical Research
MK 677 has displayed multiple effects in vivo, including:
- Increase in GH levels
- Increase in muscle mass and lean body mass
- Reduced body fat
- Increase in bone density
- Faster muscle growth
- Improved immune function
- Improved REM sleep
- Increased appetite
- Reversal of growth hormone deficiency
- Alleviation of pathology related to beta amyloid
Potential side effects of Ibutamoren
However, it must be emphasized that MK 677 has not been approved by the Food and Drug Administration (FDA) for human consumption and efficacy. The severity of documented side effects like water retention, angiogenesis, and changes in blood pressure and blood sugar are still being determined. Potential drug interactions are also unknown at this time so caution is critical with this compound.
Since it has a very long half life, there is a some concern that sustained administration of MK-677 can overstimulate or desensitize the ghrelin receptor in the human brain. Perhaps the most immediately noticeable side effect of Ibutamoren at this time is a significant increase in appetite and hunger.
It is in the preclinical stages of investigation for GH-deficiency and should be used for research purposes only. Further important research into MK-677 will be performed in the years to come.
Why is Sports Technology Labs the best liquid MK 677 to buy online?
Many companies have ibutamoren for sale, but Sports Technology Labs is the best place to buy MK 677 online because of their consistent, verifiable high quality products, safe bottling and packaging, fast shipping, and great customer service.
When you buy SARMs from Sports Technology Labs you are choosing the highest quality ingredients. Minimum 98% pure compounds tested and certified by accredited American third party labs, suspended in USP grade (the highest grade) PEG400, bottled in America. Our products come in glass bottles with fixed glass droppers to prevent the leaching of unwanted plasticizers like BPA, and prevent contamination between testing with external measuring tools.
